BIOFLOW® CHECK VALVES

safety for high-purity processes

BioFlow® check valves are designed to ensure optimal flow control in aseptic and high-purity processes. With their innovative, elastomer-free sealing technology, they provide maximum reliability, durability, and resistance to aggressive and abrasive media. Engineered for seamless integration into demanding production environments, BioFlow valves minimize contamination risks and support efficient cleaning processes. Their high-performance design ensures smooth operation, contributing to the safety and efficiency of critical fluid handling systems.

NEUMO BioFlow®

NEUMO BioFlow® check valves feature a unique shut-off element FLOWstop that ensures optimal performance across a range of high-purity and sterile applications. They are specifically designed to prevent the backflow of condensate and are ideally suited for use in ultra-pure steam, ultra-pure water, and WFI (Water for Injection) systems. These valves play a critical role in protecting sensitive sterile pumps and instruments from pressure surges, thereby enhancing the reliability and longevity of equipment. NEUMO check valves are also used in sampling systems for the controlled delivery of WFI and ultra-pure water, as well as in compressed air and pressure flushing processes within sterile environments, where cleanliness and system integrity are paramount.

Benefits of BioFlow® with FLOWstop

The NEUMO BioFlow check valves with FlowStop offer significant advantages for high-purity applications. Their cGMP-compliant design features an exceptionally clean, dead-space-free structure with a pharmaceutical-grade surface finish and uniform flow profile, ensuring optimal cleanability and anti-fouling performance. Technically, the FlowStop operates without springs or membranes and relies on a single moving part guided by the valve housing itself—offering a robust, state-of-the-art solution with minimal complexity. Economically, these valves help reduce maintenance costs and system downtime, eliminate the need for additional components like orifice plates or flow sensors, and lower the risk of process interruptions, making them a highly efficient and reliable choice for pharmaceutical and bioprocessing environments.

Key Technical Characteristics of Check Valves

Check valves play a crucial role in controlling media flow within piping systems. They operate automatically, without external actuators, and allow flow in only one direction. When the pressure or flow conditions change, the valve responds instantly by opening or closing as needed. This self-acting mechanism ensures reliable reflow prevention, protects pumps and sensitive instruments, and helps avoid damage caused by water hammer. With quick reaction times and robust design, check valves are essential for maintaining the safety and efficiency of demanding process environments.

cGMP-Compliant Valve Requirements for Sterile Applications

When used in pharmaceutical production and sterile environments, valves must meet stringent requirements in accordance with current Good Manufacturing Practice (cGMP) regulations. Key expectations include the effective avoidance of contamination and cross-contamination, as well as the prevention of product fouling. Additionally, valves must offer optimal cleanability—supporting thorough and reproducible cleaning processes—while maintaining low differential pressure to ensure efficient and gentle product flow. These criteria are essential for maintaining product integrity, safety, and regulatory compliance in critical hygienic applications.

Check Valve BioFlow HVC

Hygienic, Reliable, cGMP-Compliant

BioFlow HVC check valve with BioConnect® body seal is specifically designed for sterile applications in the pharmaceutical, biotechnology, and food industries. It reliably prevents backflow, protects sensitive equipment, and meets the highest hygiene and safety standards.

With horizontal installation, dead-leg–free design, and excellent cleanability, the valve complies with cGMP regulations and meets FDA and USP Class VI requirements. The specially developed CleanLip seal made of EPDM or optional PTFE ensures outstanding sealing performance and chemical resistance.

Key Technical Features

  • Materials: 1.4435 / 316L stainless steel; sealing materials FDA & USP Class VI compliant

  • Surface finish: Ra ≤ 0.8 μm (electropolished)

  • Max. operating pressure: PN16 (at 20 °C)

  • Temperature range: –10 °C to +150 °C

  • Opening pressure: 0.02 bar

  • Connections: Orbital weld ends according to DIN 11866 / ISO / ASME BPE

  • Approvals: EHEDG, TÜV-tested housing

The BioFlow HVC is the ideal solution for hygienic processes where safety, backflow prevention, and cleanability are critical.

Check Valve BioFlow VC

Compact Vertical Design for Aseptic Applications

BioFlow VC check valve with BioConnect® body seal is designed for vertical installation in sterile process systems. Its compact construction, combined with high-quality materials and optimized hygienic design, ensures reliable backflow prevention in applications across the pharmaceutical, biotech, and food industries.

Manufactured from 1.4435 / 316L stainless steel, the valve features a FLOWstop sealing element made of FDA- and USP Class VI-compliant EPDM or PTFE. The BioConnect® CleanLip body seal ensures excellent sealing performance, easy cleanability, and high chemical resistance. A delta ferrite content of < 1% and an electropolished surface finish of Ra ≤ 0.8 μm further support hygienic process integrity.

Key Technical Features

  • Materials: 1.4435 / 316L stainless steel; seal type BioConnect® CleanLip with EPDM O-ring (FDA + USP Class VI)

  • Delta ferrite content: < 1%

  • Surface finish: Ra ≤ 0.8 μm, electropolished

  • Max. pressure: PN16 (at 20 °C)

  • Opening pressure: 0.02 bar

  • Temperature range: –10 °C to +150 °C

  • Connections: Orbital weld ends according to DIN 11866 (A), ISO (B), or ASME BPE (C)

  • Approvals: TÜV component-tested housing, EHEDG (housing)

This check valve is ideal for hygienic applications requiring compact vertical flow control with the highest standards of cleanliness, safety, and regulatory compliance.

Check Valve BioFlow VC / HVC

Elastomer-Free with ConnectS® Body Seal

BioFlow VC and HVC check valves with the ConnectS® body seal system offer reliable, hygienic flow control for critical applications in the pharmaceutical, biotech, and food industries. Whether installed vertically (VC) or horizontally (HVC), these valves ensure aseptic integrity with an elastomer-free sealing concept, ideal for highly demanding, clean environments.

The valves are made from 1.4435 / 316L stainless steel, with options for FDA- and USP Class VI-compliant EPDM or PTFE sealing elements. The ConnectS® body seal ensures a tight, sterile closure without the use of traditional elastomers in the product-wetted area (HVC version). Both valves are engineered for durability, cleanability, and easy integration into orbital welded systems.

Key Technical Features

  • Installation:
    • BioFlow VC: vertical
    • BioFlow HVC: horizontal
  • Materials: 1.4435 / 316L stainless steel
  • FLOWstop material: EPDM (FDA + USP Class VI, vulcanised); PTFE (FDA + USP Class VI); 1.4435/316L (elastomer-free option)
  • Delta ferrite content: < 1%
  • Surface finish: Ra ≤ 0.8 µm (electropolished)
  • Max. pressure resistance:
    • FLOWstop Ø 37 + 55 → PN16 (at 20°C)
    • FLOWstop Ø 65 + 99 → PN10 (at 20°C)
  • Opening pressure: 0.02 bar
  • Temperature range: –10°C to +200°C
  • Connections: Orbital weld ends in accordance with DIN 11866 line A (DIN), line B (ISO), or line C (ASME-BPE)
  • Approvals: TÜV component-tested (housing); EHEDG (housing); TA-Air (housing)

These valves are the perfect choice for hygienic process systems that demand metal-to-metal sealing, minimized contamination risk, and full compliance with the strictest industry standards.

Check Valve BioFlow TCVC

Body Seal with Tri-Clamp Connection

Check Valve BioFlow TCVC combines proven aseptic design with the practical benefits of Tri-Clamp connections for fast installation and easy maintenance in hygienic environments. Designed for vertical installation, this valve is ideal for applications in the pharmaceutical, biotechnology, and food industries, where cleanability, safety, and compliance are critical.

The valve housing is made from 1.4435 / 316L stainless steel, and is available with a FLOWstop sealing element made from EPDM or PTFE, both FDA- and USP Class VI-compliant. The body seal is integrated as a Tri-Clamp gasket, ensuring compatibility with DIN 32676 and ASME-BPE standards. With a precise turned surface finish and orbital welding connections, the TCVC valve delivers both performance and hygiene.

Key Technical Features

  • Installation: Vertical

  • Materials: 1.4435 / 316L stainless steel

  • FLOWstop Material:
    • EPDM (FDA + USP Class VI, vulcanised)
    • PTFE (FDA + USP Class VI)

  • Body Seal: Clamp seal EPDM (FDA + USP Class VI), compliant with DIN 32676 and ASME-BPE

  • Max. Pressure Resistance: PN10 (20°C)

  • Opening Pressure: 0.02 bar

  • Temperature Range:
    • –10°C to +150°C (EPDM)
    • Up to +200°C with PTFE FLOWstop and housing seal

  • Surface Finish (Product Contacted Area): Ra ≤ 0.8 µm, precision turned

  • Delta Ferrite Content: < 1%

  • Connections: Orbital weld ends according to DIN 11866 line A (DIN), line B (ISO), or line C (ASME-BPE)

This valve design enables quick assembly and disassembly, reduces downtime during maintenance, and ensures full compatibility with standard hygienic pipe systems.

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NEUMO GmbH + Co. KG
Zeppelinstraße 21
75438 Knittlingen
Germany